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FOXO4-DRI improves the testicular microenvironment in naturally aged mice FOXO4-DRI-treated aged testes showed decreased interstitial SA--gal activity (Figure 7A) as well as lower levels of senescence-associated proteins p53, p21, and p16 (Figure 7B7E)

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Latent fatigue was gone and mental performance sharply increased

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Future research should prioritize well-designed epidemiological studies and randomized controlled trials in underrepresented income settings, as well as systematic reviews that formally assess risk of bias and regional underrepresentation in the literature