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The team confirmed that 1) CBS protein and H2S levels were elevated in DS cells, 2) that mitochondrial metabolism is impaired in these cells, and 3) demonstrated that CBS inhibition or downregulation improves bioenergetic functions, restores mitochondrial Complex IV activity and consequently improve viability and proliferation rate in DS cells (Panagaki et al 2019)

Mol Cell Biol 19(4):24352444

doi: 10.3390/ijms26062548 87 AzlanASultanaSHueiCSRazmanMR

Twice-Daily Fludarabine and Cytarabine Combination With or Without Gentuzumab Ozogamicin is Effective in Patients With Relapsed/Refractory Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, and Blast- Phase Chronic Myeloid Leukemia

Likewise, steer clear of whitening supplements with potentially harmful ingredients like high mercury or hydroquinone

doi 10.3390/nu16223951