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Wild-type TTR amyloidosis primarily affects the heart, and although often asymptomatic, amyloid deposits can be detected in approximately 25% of men over 80 years of age [5], making TTR amyloidosis one of the most common amyloid disorders

Cell Biol Int (2020) 44:72134

These findings suggest that HHcy-induced organ and tissue damage may stem primarily from the loss of endothelial barrier integrity and function [37,38,39,40,41]

Pathogenetically, PD emerges as a multisystem disorder, with peripheraltocentral pathways playing critical roles in disease onset and progression

Indeed, oxidation damage is highly dependent on the inherited or acquired defects in enzymes involved in the redox-mediated signaling pathways

Chem Commun 56:715718