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Additionally, the integrated HIV-1 provirus is approximately 9700 bp in length, and HIV-1 Rev binds directly to the Rev response element, leading to the accumulation of unspliced, partially spliced, and fully spliced RNA species, as well as rare cryptic splice donors (5 splice sites) and acceptors (3 splice sites) [38]

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Hereditary glutathione reductase deficiency generally impairs cellular energy balance and increases the level of oxidative stress in red blood cells and has been related to hereditary hemolytic anemia 9,10