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El-Saadony, T

But actually, you know, we used to do physical labor as a species

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Both chemotherapeutic agents (such as cisplatin and paclitaxel) and targeted therapeutic drugs (such as EGFR inhibitors and BRAF inhibitors) can induce resistant phenotypes in cancer cells after prolonged use ( 1.2 The unique significance of ferroptosis Ferroptosis was formally defined in 2012 as a form of regulated cell death that depends on iron ions and is triggered by the accumulation of lipid peroxides ( For instance, in drug-resistant lung adenocarcinoma, ferroptosis sensitivity is markedly enhanced due to upregulated ACSL4 expression and metabolic reprogramming, which synergize with immune crosstalksuch as CD8+ T cell-derived IFN-to overcome therapy resistance ( Notably, specific cancer subtypessuch as triple-negative breast cancer, lung adenocarcinoma, clear cell renal carcinoma, and mesenchymal-type tumors with high metastatic potentialexhibit heightened susceptibility to ferroptosis due to their inherent metabolic reprogramming, iron overload, and antioxidant system deficiencies

Patient heterogeneity, long disease course, and variability in clinical presentation complicate recruitment, stratification, and outcome measurement