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Regulation of FSP1 myristoylation by NADPH: a novel mechanism for ferroptosis inhibition

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1.11.1.6) is a tetrameric ferriheme oxidoreductase, which catalyzes H 2 O 2 dismutation to water and gaseous oxygen, as shown in reaction 3 ( CAT is mainly located in peroxisomes, and despite being ubiquitous, the highest activity is present in liver and red blood cells

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This crosstalk amplifies neuroinflammatory signaling and alters neurovascular integrity, contributing to blood-brain barrier disruption, glial priming, and neuronal injury 11-12