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These results provided the hypothesis that glycolysis in astrocytes results in a production of 2 molecules of ATP which are then consumed by the formation of Glu from Gln which suggests a tight coupling between the two mechanisms
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This was investigated in the present clinical trial of 83 patients, randomised to the bumetanide group (bumetanide treatment, 0.5 mg twice daily) or the control group (no bumetanide treatment)
JAMA 310 , 24352442 (2013)
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