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The evidence was based on experimental data only briefly described in the patent and included models of: gastric ulcers, heart damage, liver damage, pancreatic injury, kidney damage, experimental diabetes, fever, edema, rhinitis, bone fracture, burns, skin wounds, hypersensitivity reactions, pupil dilation, colon injury, tumour growth, radiation injury, red blood cell development, fertility and lactation, tooth damage, several types of central and peripheral nerve damage, and survival from infection with Trichinosis (i.e., tapeworms) as well as several viruses

Melatonin synthesized in the pineal gland is rapidly and pulsatilely released into the bloodstream and cerebrospinal fluid, from where it is distributed to organs and tissues throughout the body. MELATONIN RECEPTORS Activation of melatonin receptors determines the subsequent biological effects

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Enhances phases of sleep that support physical recovery, metabolic restoration, and cognitive processing