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In conditions like Alzheimers, reduced GPx activity permits reactive oxygen species to accumulate, leading to protein misfolding and neuronal death

Alpha Lipoic Acid: A potent antioxidant supporting cellular energy and skin health

doi: 10.1016/S0140-6736(16)00082-9

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Its protective mechanism involves inhibiting the STING signaling pathway, thereby promoting the polarization of microglial cells towards the M2 anti-inflammatory phenotype, reducing the expression of pro-inflammatory factors (such as TNF-, IL-1, NLRP3), and increasing the expression of anti-inflammatory factors (such as CD206, Arg1, IL-10), thereby alleviating neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage

Granzyme K Expressed by classically activated macrophages contributes to inflammation and impaired remodeling