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Interestingly, microglia isolated from whole brains of aged mice (21-months-old) show significantly downregulated expression levels of TREM2 compared to younger mice (Hickman et al., 2013
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Biochemistry 2004, 43 (39), 1258512591
The severe insulin-deficient diabetes (SIDD) subtype is characterised by high HbA 1c , low HOMA-B and low HOMA-IR , resembling adult-onset type 1 diabetes but in the absence of autoantibodies
