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No criteria exist to establish when a neurological syndrome is pathogenically linked to GAD antibodies, often leading to the assumption that any syndrome in which these antibodies are present is immune mediated, sometimes resulting in misdiagnosis and unnecessary treatment

328,329,330,331 In a porcine model of chronic myocardial I/R, the inhibition of calpain activity resulted in the upregulation of both PI3K and Wnt/-catenin pathways

In copper-based catalytic systems, sustained GSH-driven copper redox cycling can generate hydroxyl radicals (OH), causing acute oxidative damage and inducing apoptosis in cancer cells 183-185

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(2016) Nuclear localization of glutamate-cysteine ligase is associated with proliferation in head and neck squamous cell carcinoma, Oncol