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These PAMs enhance the function of GluN1/GluN2A diheteromers or GluN1/GluN2A/GluN2B triheteromers, which are the predominant species of NMDARs located at the synaptic cleft in mature neurons [133]

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[DOI] [PubMed] [Google Scholar] 227.Boyles AL, Deroo LA, Lie RT, Taylor JA, Jugessur A, Murray JC, Wilcox AJ

Animal models show this peptide induces concentration-dependent vasodilation, an effect that was diminished when NO synthesis was inhibited

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Occasionally, patients have reported a donut-like or cratering effect months after treatment due to the filler settling around the scar, making the scar more pronounced