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Earlylife adversity during critical developmental periodsincluding intrauterine stress, maternal stress, low birth weight [180], neonatal intensive care admission [181], and childhood traumais consistently associated with heightened pain sensitivity [182] and a markedly increased risk of developing chronic overlapping pain conditions in adulthood [183, 184, 185]

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Oxidative stress (distress) is a common denominator of a wide range of diseases including cancer, neurological disorders such as Alzheimers disease, lung diseases, cardiovascular diseases and other disorders collectively characterized by multiple mechanisms by which ROS cause cellular damage