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KPV requires PepT1 transport into cells, where it blocks NF-B and MAPK pathways at the source

(2017) 152:e171505

doi: 10.1134/S1990747822030096 301 YangH.-M

Targeting glucose metabolism to overcome therapeutic resistance Since glucose metabolism regulates the DDR through both metabolite signaling and enzymatic crosstalk, targeting these metabolic dependencies offers an avenue to compromise cellular defense mechanisms and resensitize cancers to genotoxic treatments (Table 2)