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doi: 10.1249/JES.0000000000000050

They are: Not FDA-approved for wrinkle reduction Not supported by large clinical trials for cosmetic use Lacking standardized dosing and safety data The only injectable peptides currently approved by the FDA are GLP-1 medications (such as semaglutide and tirzepatide), and these are approved for diabetes management and weight loss, not cosmetic purposes

In Drosophila, the SLC25A39/40 homolog Shawn localizes to mitochondria, and its loss increases ROS accumulation, disrupts mitochondrial function, and causes progressive neurodegeneration 13

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Circumference measurements: Waist, hip, arm, and thigh measurements track where changes occur

Activation of OXGR1 by binding 2-oxoglutarate leads to the regulation of a signal transduction pathway involving signal transducer and activator of transcription-3 (STAT-3)