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Heme as key regulator of major mammalian cellular functions: Molecular, cellular, and pharmacological aspects

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Under these conditions, the enzyme -glutamylcysteine ligase continues to produce large quantities of -glutamylcysteine, which is converted by -glutamyl cyclotransferase into 5-oxoproline (Figure 1C)

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& Sorensen, N

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doi: 10.1007/978-3-319-41334-1_2 17 CostaL

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Through its effects on the metabolism of catecholamine neurotransmitters and estrogen, COMT is emerging as a key player in the pathogenesis of AD

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Another way is that ABCC proteins entrap arsenite in the vacuole as PCs-As(III) (Zhang et al

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