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Heme as key regulator of major mammalian cellular functions: Molecular, cellular, and pharmacological aspects

Under these conditions, the enzyme -glutamylcysteine ligase continues to produce large quantities of -glutamylcysteine, which is converted by -glutamyl cyclotransferase into 5-oxoproline (Figure 1C)

& Sorensen, N

doi: 10.1007/978-3-319-41334-1_2 17 CostaL

Through its effects on the metabolism of catecholamine neurotransmitters and estrogen, COMT is emerging as a key player in the pathogenesis of AD

Another way is that ABCC proteins entrap arsenite in the vacuole as PCs-As(III) (Zhang et al
