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Three primary routes have been characterised in research: Vagal-cholinergic pathway: BPC-157 activates afferent vagal fibres, driving NTS (nucleus tractus solitarius) PVN (paraventricular nucleus) cortical signalling

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Notably, BPC-157 counteracts both arterial and venous thrombosis while promoting vessel circumvention in ischemia-reperfusion scenarios

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The dominant model is acute surgical transection or chemical injury in rats, evaluated over short-to-medium time courses