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Although allogeneic or xenogeneic cell sources have been explored in animal models [96, 97], their clinical translation is constrained by potential immune rejection, ethical concerns, and a lack of supporting human data

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Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis

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van Hoppe S, Rood JJM, Buil L, Wagenaar E, Sparidans RW, Beijnen JH, Schinkel AH (2018) P -glycoprotein (MDR1/ABCB1) restricts brain penetration of the Brutons tyrosine kinase inhibitor ibrutinib, while cytochrome P450-3A (CYP3A) limits its oral bioavailability