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Increased levels of miR-144 have been found in a subset of HbSS patients with typical severe anemia and reduced NRF2 protein levels, causing a reduction of GSH regeneration and impairing cell response to OS, thereby providing a possible mechanism for the increased anemia severity seen in these patients [221]

Perry J

Randomized double-blind placebo-controlled (RDP) clinical trials help clarify and confirm some of the mechanisms of action of Pycnogenol at the molecular level

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