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Effects of natural polyphenols on the expression of drug efflux transporter P-glycoprotein in human intestinal cells

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Twice-daily dosing is used in some early-phase research protocols to maintain more consistent receptor activation during the initial neuroplasticity induction period, but this approach increases total daily exposure and may elevate the risk of off-target effects

In another study of patients with left ventricular dysfunction, supplementation with 150 mg/day of coenzyme Q 10 for four weeks before cardiac surgery increased coenzyme Q 10 concentrations in the heart but not in skeletal muscle (107)

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