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On the other hand, to detail the effects of butyrate on host metabolism and further promote butyrate as a therapeutic approach for designing novel clinical trials, it is critical to identify its effects on different animals and humans and evaluate different doses, treatment times and delivery methods

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Increased ROS production has important consequences with respect to signaling by the soluble guanylate cyclase and the cyclic guanosine monophosphate-dependent kinase I, whose activity and expression has been shown to be regulated in a redox-sensitive manner
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