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The second line of antioxidant defense involves the synthesis of a thioredoxin redox system in which reduced thioredoxin (TRX) catalyzes the reduction of disulfides (SS) and is itself oxidized and subsequently reduced by thioredoxin reductase at the expense of NADPH

[DOI] [PubMed] [Google Scholar] 191.Fu X., Cate S.A., Chen J., zpolat T., Norby C., Konkle B.A., Lopez J.A

27,28 In addition to loss of dopaminergic neurons, cholinergic neurons are also at risk

[DOI] [PubMed] [Google Scholar] 402.Jiang J., Mehrabi Nasab E., Athari S.M., Athari S.S

Hoang N

Ferroptosis has been implicated in a number of disorders such as neurodegenerative diseases (amyotrophic lateral sclerosis (ALS), Alzheimers disease (AD), Parkinsons disease (PD), and Huntingtons disease (HD), etc.), ischemia/reperfusion injury, and kidney degeneration