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Neoplastic cells may evolve adaptive pathways to circumvent drug-induced cytotoxicity, including enhanced drug efflux, DNA repair activation, and apoptotic signaling dysregulation (Patel and Kumar, 2025

Furthermore, the inhibition or reduced activity of PDI due to oxidative stress could have impact on SARS-CoV-2 infection

Despite treatment, the woman is unable to verbalize or care for herself, requiring an ongoing feeding tube for nutritional support.

This mismatch is further complicated by the fact that standard thyroid panels typically exclude fT3 and rT3 measurements, which can render tissue-level hypothyroidism undetectable through conventional testing

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