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Overproduction of free radicals such as reactive oxygen species and reactive nitrogen species leads to oxidative stress, which is associated with the pathophysiology of various human diseases including cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases (Alzheimer disease and Parkinson disease), rheumatoid arthritis, and ageing

Lab Anim Res 33(1):2431

Whilst this small molecule has received a conditional approval as a treatment modality for FRDA in Canada (Santhera Pharmaceuticals, Liestal, Switzerland) (Hawi et al., 2012), other countries including the United States areyet to consider the approval of Catena as a treatment for FRDA

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This can impair energy production, cause muscle weakness, and potentially contribute to liver complications such as PN-induced cholestasis

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