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Methionine plays a central role in counteracting oxidative stress through its involvement in the methionine-glutathione pathway [92]

10.1080/03602532.2017.1306544 100 WangL.ShengW.TanZ.RenQ.WangR.StoikaR.et al (2021b)

DHODH holds a pivotal position in the biosynthetic pathway of pyrimidine nucleotides, playing a crucial role in the production of DNA and RNA (49), Inhibition of DHODH disrupts this pathway, leading to abnormalities in, or cessation of, pyrimidine nucleotide synthesis

Instead, it relies on a complex interplay of neurotrophic factors, immune modulation, vascular remodeling, and synaptic reorganization

[DOI] [PubMed] [Google Scholar] [8].Butterfield DA, Lauderback CM

Importantly, none of the mice died