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[10] Other uncommon adverse effects reported with very high doses include dermatological lesions (photosensitivity and skin rash), gastrointestinal upset, and in some cases dependency syndromes (e.g

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Biomed Pharmacother 57:145155

This means Vegetarians and Vegans with struggle to get enough through their natural diet

These factors include haem oxygenase-1, which has important anti-inflammatory properties toward cytokines including upregulating IL-10, and downregulating IL-6 and TNF through other means, such as NF-B signalling