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A decrease in NAD + levels directly affects the metabolism of the bodys three major energy substances: sugar, fat, and protein, inducing MetS ( + levels across various mouse tissues, including adipose (Yoshino et al., 2011), skeletal muscle (Trammell et al., 2016), and hypothalamus (Sasaki et al., 2014), concomitant with the development of obesity

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doi: 10.2174/13816128113199990462 49

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