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Theoretical concerns The limited human research on these peptides means some potential concerns remain theoretical: Cancer risk: Any peptide that promotes cell proliferation and blood vessel formation raises questions about potential effects on existing tumors

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Acknowledgements This work was partly supported by Associazione Italiana Ricerca sul Cancro (AIRC) (IG2014-15197 to L.F.) and by grants from the University of Chieti-Pescara G