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doi: 10.1186/s12916-024-03609-3

To identify the intracellular localization of AF546HPX, HL-60 cells were co-stained with markers for early endosomes, e.g

Its cardiac effects are indirect and GH-IGF-1-mediated: in post-MI C57BL/6J mice receiving CJC-1295 non-DAC at 10 g/kg 3/week for 4 weeks, LVEF improves from 38 3% to 44 4% an effect blocked by IGF-1R antibody (6872%), confirming IGF-1R-mediated cardiomyocyte survival as the mechanism