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This hypothetical mechanism is anticipated to be very rapid mode of regulation required to adjust O 2 production and ROS emission by mitochondria in response changes in redox environment (Figure 3)

Sikiric P, Seiwerth S, et al

Through this pathway, lactate disrupts AMPK signaling, which in turn downregulates sterol regulatory element-binding protein 1 (SREBP1) and its downstream target stearoyl-CoA desaturase 1 (SCD1)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Molhoek K.R., Erdag G., Rasamy J.K., Murphyg C., Deacon D., Patterson J.W., Slingluff C.L., Jr., Brautigan D.L

doi:10.2174/138920009789375423 Lin SC, Ho CT, Chuo WH, Li S, WangTT, Lin CC