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Sodium-glucose cotransporter-2 inhibition reduces cellular senescence in the diabetic kidney by promoting ketone body-induced nrf2 activation

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Supplementing beef heifer during the first 63d of gestation with one-carbon cycle components (dietary RPM, rumen-protected choline, and injection of vitamin B 12 and folic acid) increased the availability of vitamin B 12 , folate and folate intermediates in maternal serum and promoted greater levels of 5-CH 3 -THF in the allantoic and amniotic fluid (Syring et al., 2024)

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Elevated ROS levels exert a paradoxical effect: while excessive ROS can be cytotoxic, moderate overproduction contributes to tumorigenesis by inflicting oxidative damage on DNA