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10.1016/j.pharmthera.2011.10.006 170 ZhuD.LiangR.LiuY.LiZ.ChengL.RenJ.et al (2022)

Glucose-6-phosphate is oxidized to 6-phosphogluconolactone by glucose-6-phosphate dehydrogenase (G6PD) with the transfer of two electrons to NADP+ to form NADPH

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Pharmacokinetic modeling in human [2] volunteers further validates that this selectivity enables a predictable, dose-dependent growth hormone response that mimics natural pulsatile dynamics without off-target endocrine interference

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