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This interest peaked, according to PubMed, with 132 articles on AO published in 2018 alone [44]

10.1155/2018/1056173 133 SchumackerP

Attenuation of this process results in the buildup of cargo proteins, which can trigger ER stress and activate the UPR response system, and prolonged ER stress caused by misfolded proteins has been linked to ROS production, possibly due to higher levels of protein folding activity in the ER lumen

Lower glutathione levels seem to go hand-in-hand with poorer health

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Increased Lean Muscle Mass Growth hormone plays an important role in protein synthesis and muscle repair