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Endocrinology, 2001 AJP-Endocrinol Metab, 2001 Rodent & human adipose (ex vivo): AOD peptides increased lipolysis and reduced lipogenesis

Extended treatment continued to limit body weight gain and white adipose tissue mass, lowered total plasma cholesterol, and showed measurable accumulation in adipose tissue consistent with the compounds lipophilic profile

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These changes occurred through direct effects on adipocyte biology rather than appetite suppression, as research models maintained normal feeding behavior while exhibiting significant reductions in individual adipocyte size

Genotoxicity evaluation encompassed an Ames mutagenicity evaluation, a chromosomal aberration assay in Chinese hamster ovary (CHO) cells, and a bone micronucleus assay incorporated within a 4-week toxicology study in murine models