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The key components of this mechanism are oxidant stress, with ferrous iron-mediated Fenton reaction and LPO as the terminal events [62]

Oxidative Stress in the Pathogenesis of Disease Oxidative stress participates in the pathogenesis of diverse inflammatory and metabolic diseases across multiple organs, including musculoskeletal diseases, cardiac diseases, dermatological diseases, cancer, obesity, diabetes, and hypertension (Figure 4)

5:010068 [DOI] [PMC free article] [PubMed] [Google Scholar] Homma T, Kobayashi S, Fujii J (2019) Induction of ferroptosis by singlet oxygen generated from naphthalene endoperoxide

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Cochrane Database Syst Rev 1:CD003917 Van Schooten FJ, Nia AB, De Flora S, DAgostini F, Izzotti A, Camoirano A, Balm AJ, Dallinga JW, Bast A, Haenen GR, Vant Veer L, Baas P, Sakai H, Van Zandwijk N (2002) Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers