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As an important second messenger of signals, ROS can regulate cell death and cell proliferation (Covarrubias et al., 2008)

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The intricate connections among various cell death pathways are confusing: is lipid peroxidation a direct cause of cell death, or does it initially induce one type of cell death and subsequently another [276, 277]

Although it is considered an activator of AMPK, evidence supports the involvement of alternative AMPK-independent pathways, suggesting that further research is warranted (Top et al., 2022)