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Common Criticisms No platform is without complaints

60 (Suppl 7): 161-165

doi: 10.1016/j.cotox.2017.01.012

Although the overall evidence suggests that at least a subset of patients with ME/CFS exhibit reduced cortisol output, some cohorts show only modest reductions, preserved cortisol output, or context-dependent abnormalities rather than stable hypocortisolism, indicating that HPA-axis dysfunction in ME/CFS is likely heterogeneous and multifactorial rather than a specific or uniform neuroendocrine abnormality (Tomas et al., 2013

During feeding periods, the glucose spikes (and their sequelae) can be mitigated by low-carbohydrate diets, which restrict carbohydrates and increase fat to at least 40% of energy intake, and particularly by ketogenic diets, which restrict carbohydrates even further and increase fat to at least 70% of energy intake [179]

Avoid rubbing the injection site, as this can increase inflammation and bruising