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It degrades

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It is the core structure for distributing mechanical loads, enabling bending movements, and providing shock absorption in the spine, with its good elasticity and osmotic properties providing flexibility and stability to the spine ( Anatomically, the annulus fibrosus tightly encircles the nucleus pulposus in a lamellar fashion

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These tests (discussed below and in Table 1) include measures of serum, fecal, and urine biomarkers that are altered as a consequence of intestinal barrier dysfunction (i.e., inflammation) or that directly assess barrier permeability (i.e., endotoxin)