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In addition, in vivo and in vitro experimental showed that tumor necrosis factor- (TNF-)-mediated BBB breakdown is linked to COXs up-regulation the expression and activity of matrix metalloproteinases (MMPs) (Mark et al., 2001
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Other key parameters, such as surface area, volume, hydration energy, refractivity, polarizability, mass, total energy, dipole moment, and the root mean squared (RMS) gradient were also estimated for all compounds (Table2)
The results came from a sub-analysis of the REDEFINE-1 trial and showed that cagrilintide led to significant weight loss in adults with overweight or obesity that did not have diabetes
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