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The p38 branch of the mitogen-activated protein kinase (MAPK) pathway enhances the secretion of pro-inflammatory factors, including TNF-, and augments phagocytic activity (178)

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However, its role in weight loss is gaining attention for a good reason

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Emma F, Nesterova G, Langman C, Labbe A, Cherqui S, Goodyer P, Janssen MC, Greco M, Topaloglu R, Elenberg E, Dohil R, Trauner D, Antignac C, Cochat P, Kaskel F, Servais A, Wuhl E, Niaudet P, Vant Hoff W, Gahl W, Levtchenko E (2014) Nephropathic cystinosis: an international consensus document

GSSG is subsequently reduced back to GSH in the body via the enzyme glutathione reductase by utilizing the reducing agent NADPH