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Regular supplementation with vitamin C (0.25 to 2 g/day) did not reduce the incidence of colds in the general population (23 trials)

But most supplements, including glutathione, could cause a reaction in some people, notes the National Institutes of Health (NIH)

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Extended use isnt well-studied in humans, so most experts recommend cycling it, typically 48 weeks on, followed by a few weeks off, to support safety and effectiveness.

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