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This work was supported by grants from the National Natural Science Foundation of China (32250410298), the Science and Technology Planning Project of Shenzhen Municipality (KCXFZ20211020164543007 and 20210617155253001), the Foundation of Development and Reform Commission of Shenzhen Municipality (XMHT20220104028), the Guangdong Basic and Applied Basic Research Foundation (2021A1515012141) and the Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties (SZGSP013)