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In SURMOUNT-1 (NEJM 2022, 2,539 adults with obesity), the 15 mg arm averaged 22.5% body weight loss at 72 weeks, the 10 mg arm 21.4%, and the 5 mg arm 16.0%

Too little and each unit on the syringe contains so much peptide that small drawing errors create large dosing errors

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NICE-appraised licensed alternatives such as semaglutide (Wegovy) and liraglutide (Saxenda) are available through regulated UK weight management services

[3] Gwyer D, et al

Large doses may trigger hormonal changes or alter skin bacteria, leading to pimples or worsening of existing acne