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Reactive carbonyl species in vivo : generation and dual biological effects

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TABLE 1 Classification of bacterial gamma-glutamyl transpeptidases (GGTs) into different physiological groups

Due to their heightened metabolic activity, RPE cells harbor an abundance of mitochondria and consequently represent a major source of ROS [360]

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Validation of Bioanalytical Method The validation was executed as per Guidance for industry: Bioanalytical Method Validation from the United States Food and Drug Administration ( Selectivity The selectivity of the method was evaluated by analyzing blank plasma samples prior to spiking