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In the SAD cohort, SANA was well tolerated up to 400 mg, showing adverse side effects at the highest dose (800 mg)

Lipid peroxidation induction, with H 2 O 2 or cumene hydroperoxide, and exogenous 4-HNE treatment each recapitulate the LDE-adduct export impairment that occurs during ferroptosis ( Figure 4-5 )

Hensrud DD, Burritt MF, Hall LG

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The central challenge for this fungal pretreatment, however, is economic: the process is often slower and less amenable to continuous industrial operation than established physicochemical methods (e.g., steam explosion, acid hydrolysis), raising concerns about capital costs and volumetric productivity at scale (Zhu et al., 2024)