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Choline Plays a crucial role in overall cardiovascular health by reducing the risk of atherosclerosis, as well as metabolizing hepatic cholesterol

However, it is not clear what contributed specifically to this effect on inflammation, though increasing evidence suggests that IGF-1 signaling is critical for maintaining immune cell homeostasis 44 , but the prospects of sex differences in the requirement for IGF-1 signaling in these cells is not yet known and will require further study

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