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The primary safety concerns include immunogenicity (development of antidrug antibodies), gastrointestinal reactions, and contamination risks in unregulated products
The systemic inflammatory response generated by the production of cytokines and chemokines during intestinal I/R injury might profoundly disrupt the bloodbrain barrier (BBB) (Guo et al., 2025)
1 Introduction Cynaroside, also known as luteolin-7-O-glucoside, is a natural flavonoids compound
As BALB/c mice are melatonin deficient but receptor competent (28), this model allows for the assessment of receptor-mediated versus receptor-independent effects of exogenous melatonin administration in the context of ILC2-driven allergic airways disease
this is mechanistically rich but not a substitute for clinical outcome data
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