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Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency

730 FtMt protein expression is significantly upregulated in MCAO/R mice, and the absence of FtMt promotes free iron deposition and lipid peroxidation, which aggravates ferroptosis and brain injury caused by MCAO/R

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In cases of sudden, noticeable hearing loss, a hearing test may not be necessary

In fact, the dorsal motor nucleus of the glossopharyngeal and vagus nerves is where -synuclein deposition first begins in the ANS before spreading to other parts of the brain (Norcliffe-Kaufmann 2019)

NICE guidance on obesity management (CG189) emphasises evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, andwhere appropriatepharmacotherapy with licensed medications such as orlistat or semaglutide (NICE TA875)