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The examination should also include observation for a palpable defect and the Thompson test (squeezing the calf, which should result in plantar flexion in an attached tendon) to rule out rupture of the Achilles tendon

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and Pinto, R.E

6.1 Therapeutic approaches targeting circadian rhythms in kidney and eye diseases Circadian rhythm disruption plays a critical role in the pathogenesis of kidney and ocular diseases by promoting inflammation, oxidative stress, fibrosis, and hormonal imbalance

We performed the screen against 3CL using the DELopen kit and following the recommended protocol

[DOI] [PMC free article] [PubMed] [Google Scholar] 250.Sesso H.D., Buring J.E., Christen W.G., Kurth T., Belanger C., MacFadyen J., Bubes V., Manson J.E., Glynn R.J., Gaziano J.M