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Therapeutic Effects of Sulforaphane in Ulcerative Colitis: Effect on Antioxidant Activity, Mitochondrial Biogenesis and DNA Polymerization

Careful titration of JUXTAPID may then be considered based on LDL-C response and safety/tolerability to half the maximum recommended dosage except when co-administered with oral contraceptives only, in which case the maximum recommended JUXTAPID dosage is approximately two thirds of the maximum recommended dosage (Table 3) [see Dosage and Administration (2.4), Warnings and Precautions (5.6), and Clinical Pharmacology (12.3)]

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Gastroenterology, 134(1), 166178

Notably, cuproptosis is regulated by mitochondrial respiration, as supported by research indicating that mitochondria-dependent cells exhibit a sensitivity to copper ionophores nearly 1,000 times higher than cells undergoing glycolysis [12]

1 tablet a day orally and without chewing at meals